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Calcimator

Bioreactor Sizing Calculator

Determine bioreactor working volume from production targets, cell density, and specific productivity for CHO, HEK293, and other cell lines.

Inputs

%

Results

Working volume (L)

29.8

Total vessel volume (L)42.5
Nearest standard size (L)50
Vol. productivity (g/L/day)0.3
Product per L per run (g)3.36
Runs per year19
Annual capacity (kg)1.9
How to Use This Calculator
  1. Enter your target production mass in grams per batch.
  2. Set cell density (×10⁶/mL), specific productivity (pg/cell/day), and run duration (days).
  3. Adjust harvest efficiency (%) and working volume ratio for your system.
  4. Review Working Volume (L), Total Vessel Volume (L), and Nearest Standard Size (L).
  5. Check Annual Capacity (kg) to confirm the bioreactor meets your annual manufacturing targets.
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