Fermentation Scale-Up Calculator

Scale bioreactor parameters from lab to production using constant tip speed or constant P/V strategies.

Lab volume (L)

Production volume (L)

Lab agitation (RPM)

Lab impeller diameter (cm)

Strategy (0=tip speed, 1=P/V)

Tab to move between fields

Production RPM

Production impeller (cm)50

Volume scale factor1,000

Linear scale factor10

Lab tip speed (m/s)0.65

Prod tip speed (m/s)0.65

Reynolds number ratio10

Power input ratio100

How to Use This Calculator

Enter lab-scale working volume (L), production target volume (L), and lab agitation (RPM).
Set the lab impeller diameter (cm) and select scaling strategy (tip speed or power-per-volume).
Review Production RPM, Volume Scale Factor, and Linear Scale Factor.
Compare tip speed and P/V strategies to choose the best approach for your organism.
Check Reynolds Number Ratio and Power Input Ratio to assess mixing regime changes at scale.

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