Gene Therapy Dose Calculator
Calculate total vector genome dose from patient weight and target vg/kg for AAV and lentiviral gene therapies.
Inputs
%
Results
Total dose (vg)
700,000,000,000,000
Total dose (log10 vg)14.85
Dose per kg (vg/kg)10,000,000,000,000
Required conc. (vg/mL)700,000,000,000,000
Stock needed (mL)840
Bioreactor runs needed2
How to Use This Calculator
- Enter patient weight (kg), dose coefficient, and dose exponent (10^n vg/kg).
- Set virus yield (vg/mL), fill volume per vial (mL), and manufacturing overfill (%).
- Review Total Dose (vg), Required Concentration (vg/mL), and Stock Needed (mL).
- Use Bioreactor Runs Needed to plan manufacturing capacity for clinical or commercial supply.
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