Purification Yield Calculator
Calculate overall downstream purification yield from individual step recoveries for biologics manufacturing.
Inputs
%
%
%
%
%
%
%
Results
Overall yield (%)
65.34
Final product (g)32.67
Mass lost (g)17.33
After capture (g)45.13
After polishing (g)35.46
After final processing (g)32.67
Start needed for 1g final (g)76.52
How to Use This Calculator
- Enter the starting material mass in grams from the bioreactor harvest.
- Set yield percentages for each purification step (clarification, capture, viral inactivation, polishing, UF/DF).
- Review Overall Yield (%), Final Product (g), and Mass Lost (g).
- Identify the step with the greatest loss and optimize to improve overall process yield.
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