Isotope Production Calculator
Calculate activity produced from neutron irradiation given flux, cross section, and irradiation time.
About this calculator
Neutron activation is how most medical and industrial radioisotopes are made: a stable target nucleus absorbs a neutron and transforms into a radioactive product. This calculator implements the standard activation buildup equation, A(t) = N·σ·φ·(1 − e^(−λt)), where N is the number of target atoms (derived from your target mass, assuming a representative atomic mass of ~100 amu since this calculator doesn't take a specific isotope as input), σ is the activation cross section converted from barns to cm² (1 barn = 10⁻²⁴ cm²), φ is neutron flux, and λ is the decay constant of the product isotope. The term N·σ·φ alone gives the saturation activity — the theoretical maximum activity the target would reach if irradiated forever — while the (1 − e^(−λt)) factor describes how activity actually builds up asymptotically toward that ceiling, governed by the product's own half-life rather than the irradiation time itself.
This is why the calculator reports an "optimal irradiation time" of about 3.5 half-lives: beyond that point you're at roughly 91% of saturation activity, and further irradiation yields diminishing returns since production and radioactive decay of the product are approaching equilibrium. Specific activity (activity per gram of target) is useful for judging whether the product will be usable at sufficient concentration for its intended application. The main simplification to know about: assuming a flat ~100 amu atomic mass for the target is a rough stand-in rather than the true atomic mass of your specific target isotope, so treat absolute activity numbers as order-of-magnitude estimates rather than precision production planning figures.
Inputs
Results
Produced Activity
33.42 GBq
How to Use This Calculator
- Enter Target Mass, Activation Cross Section, and Neutron Flux.
- Set Irradiation Time and Product Half-Life.
- Review the Produced Activity (GBq) result.
- Use Produced Activity (mCi) and Produced Activity (Bq) to inform your decision.
- Use the chart to visualize the results and explore different scenarios by adjusting inputs.
How the result changes with Product Half-Life
| Product Half-Life | Produced Activity |
|---|---|
| 23,091 | 66.78 GBq |
| 34,637 | 44.54 GBq |
| 69,273 | 22.28 GBq |
| 115,455 | 13.37 GBq |
What each input means
- Target Mass
- Mass of the target material to be irradiated in grams.
- Activation Cross Section
- Thermal neutron activation cross section in barns. Co-59→Co-60: 37 b, Mo-98→Mo-99: 0.13 b.
- Neutron Flux
- Thermal neutron flux at the irradiation position. Research reactors: 10¹³–10¹⁵ n/cm²/s.
- Irradiation Time
- Duration of neutron irradiation in hours.
- Product Half-Life
- Half-life of the produced radioactive isotope in hours. Co-60: 46,182 hr, Mo-99: 65.9 hr.
How this is calculated
Worked example, using the default values
- Identify Input Parameters4 parametersTarget Mass = 1, Activation Cross Section = 37, Neutron Flux = 100000000000000, Irradiation Time = 100 = 5 input(s) provided
- Calculate Produced ActivityProduced Activity33.417 = 33.417
- Calculate Produced ActivityProduced Activity903.17 = 903.17
- Calculate Produced ActivityProduced Activity33417143459 = 33417143459
Engine last updated . Checked against 1 independently-derived test — how we verify calculators. Built by Paul Gunder, a software engineer, not a licensed financial, medical, or legal professional.
Frequently Asked Questions
What is saturation activity, and why can't produced activity ever exceed it?
Saturation activity (N·σ·φ) is the theoretical ceiling reached only if you irradiated the target forever — it's the activity level at which new atoms are being activated at exactly the same rate the existing product atoms are decaying away. Actual produced activity follows A(t) = A_sat·(1 − e^(−λt)), and since (1 − e^(−λt)) can only approach 1 as time grows, produced activity can approach but never reach or exceed saturation activity.
Why does the calculator suggest irradiating for about 3.5 half-lives as the optimal time?
At 3.5 half-lives, (1 − e^(−λt)) works out to roughly 0.91, meaning you've reached about 91% of the maximum possible activity. Beyond that point, each additional half-life of irradiation buys progressively less activity gain — going from 3.5 to 7 half-lives only takes you from ~91% to ~99% — so irradiation time beyond about 3.5 half-lives is generally not worth the added reactor time and cost.
Why does the calculator assume a fixed ~100 amu atomic mass for the target?
The engine doesn't take a specific target isotope as input, so it uses 100 amu as a representative stand-in to convert your entered target mass into a number of atoms via Avogadro's number. Since real target isotopes range from light elements to heavy actinides, this introduces error proportional to how far your actual target's atomic mass is from 100 — treat the absolute activity figures as order-of-magnitude estimates rather than precise production numbers unless your target happens to be near 100 amu.
What does specific activity tell me that total produced activity doesn't?
Total produced activity (in Bq) tells you the overall radioactivity generated, but specific activity (Bq per gram of target) tells you how concentrated that radioactivity is within the target material. This matters because many applications — medical isotopes especially — require the product to be usable at a minimum concentration, so a large total activity spread across a heavy target may still be too dilute for its intended use even if the raw activity number looks impressive.
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