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Calcimator

Process Scale-Up Calculator

Scale reactor agitation from lab to production using constant tip speed, constant P/V, or constant Reynolds number criteria.

Inputs

gal
gal
RPM
W
(1=tip speed, 2=P/V, 3=Re)

Results

Volume Scale Ratio

1,000×

Production Agitator Speed

30 RPM

Production Power500 W
Impeller Diameter0.6 m
Estimated Mixing Time2 s
How to Use This Calculator
  1. Enter the Lab Reactor Volume in liters and the target Production Reactor Volume in liters — the ratio defines the scale-up factor.
  2. Enter the Lab Agitator Speed in RPM and Lab Agitator Power in watts from bench-scale testing.
  3. Select the Scale-Up Criterion: 1 = constant tip speed (good for shear-sensitive processes), 2 = constant power per volume (good for mass transfer), 3 = constant Reynolds number (preserves mixing pattern).
  4. Review the Production Agitator Speed in RPM and Production Power in watts to specify the production agitator motor.
  5. Note the Impeller Diameter in meters to specify the production vessel and agitator geometry.
  6. Use the Estimated Mixing Time in seconds to assess blend time and ensure homogeneity at production scale.

How the result changes with Lab Reactor Volume

Lab Reactor VolumeVolume Scale RatioProduction Agitator Speed
10050×81.43 RPM
35014.29×123.64 RPM
6507.69×151.97 RPM
9005.56×169.39 RPM

What each input means

Lab Reactor Volume
Volume of the laboratory reactor in liters.
Production Reactor Volume
Volume of the production-scale reactor in liters.
Lab Agitator Speed
Rotational speed of the lab impeller in revolutions per minute.
Lab Agitator Power
Power consumption of the lab agitator in watts.
Scale-Up Criterion
Select criterion: 1 = constant tip speed, 2 = constant power per volume, 3 = constant Reynolds number.

How this is calculated

Worked example, using the default values

  1. Identify Input Parameters
    4 parameters
    Lab Reactor Volume = 5, Production Reactor Volume = 5000, Lab Agitator Speed = 300, Lab Agitator Power = 5 = 5 input(s) provided
  2. Calculate Volume Scale Ratio
    Volume Scale Ratio
    1000 = 1000
  3. Calculate Production Agitator Speed
    Production Agitator Speed = Math
    30 = 30
  4. Calculate Production Power
    Production Power = Math
    500 = 500
  5. Calculate Impeller Diameter
    Impeller Diameter
    0.5985 = 0.5985

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