BNP Interpreter Calculator
Interpret BNP or NT-proBNP levels for heart failure diagnosis with age-stratified cutoffs and renal/obesity adjustments.
Medical Disclaimer
This calculator is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about your health. Never disregard professional medical advice or delay seeking it because of results from this tool.
Inputs
Results
HF Likelihood
1
How to Use This Calculator
- Enter BNP (pg/mL) or NT-proBNP (pg/mL) — enter 0 for the marker you are not using.
- Set patient age, eGFR (mL/min/1.73m²), and BMI.
- Review HF Likelihood, Rule-Out Threshold, Rule-In Threshold, and Renal/Obesity-adjusted values.
- Values below the rule-out threshold have a >95% negative predictive value for heart failure.
What each input means
- BNP level
- B-type natriuretic peptide level. Enter 0 if using NT-proBNP instead.
- NT-proBNP level
- N-terminal pro-BNP level. Enter 0 if using BNP instead.
- Age
- Patient age. NT-proBNP cutoffs are age-stratified.
- eGFR
- Estimated glomerular filtration rate. Low eGFR elevates natriuretic peptides.
- BMI
- Body mass index. Obesity lowers natriuretic peptide levels.
What each result means
- HF Likelihood
- 0 = HF unlikely, 1 = Possible (gray zone), 2 = HF likely.
- Marker Value Used
- The BNP or NT-proBNP value used for interpretation.
- Rule-Out Threshold
- Below this threshold, HF is unlikely (NPV >95%).
- Rule-In Threshold
- Above this threshold, HF is likely. Age-adjusted for NT-proBNP.
- Renal-Adjusted Value
- Estimated value corrected for renal impairment.
- Obesity-Adjusted Value
- Estimated value corrected for obesity (BMI ≥30 may falsely lower BNP).
- Negative Predictive Value
- Confidence that HF is absent when below rule-out threshold.
How this is calculated
Worked example, using the default values
- Identify Input Parameters4 parametersBNP level = 0, NT-proBNP level = 500, Age = 65, eGFR = 60 = 5 input(s) provided
- Calculate HF Likelihood1 = 1
- Calculate Marker Value Used500 = 500
- Calculate Rule-Out Threshold300 = 300
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