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Calcimator

Celiac Probability Score Calculator

Estimate pre-test probability of celiac disease from symptoms, serology (tTG-IgA, EMA), and risk factors. Includes no-biopsy pathway eligibility assessment.

Inputs

Results

Total Score

0

Estimated Probability (%)

0%

Risk Level (0–3)0
Symptom Score0
Serology Score0
No-Biopsy Pathway (0/1)0
Next Step (0–3)0
How to Use This Calculator
  1. Enter symptom flags: Chronic Diarrhea, Bloating/Pain, Weight Loss, Iron-Deficiency Anemia, and Dermatitis Herpetiformis.
  2. Enter serologic results: tTG-IgA grade (negative, weak positive, strong positive) and Multiple of ULN.
  3. Enter EMA result, Family History, and Type 1 Diabetes status.
  4. Review the calculated probability score to stratify likelihood of celiac disease.
  5. Use the score to guide the need for duodenal biopsy confirmation.

What each input means

Chronic Diarrhea
Chronic diarrhea present (>4 weeks).
Bloating/Abdominal Pain
Recurrent bloating or abdominal discomfort.
Unexplained Weight Loss
Unintentional weight loss.
Iron-Deficiency Anemia
Iron-deficiency anemia, especially refractory.
Dermatitis Herpetiformis
Pathognomonic skin rash for celiac disease.
tTG-IgA Result
Tissue transglutaminase IgA antibody result.
tTG-IgA Multiple of ULN
tTG-IgA level as multiple of upper limit of normal. ≥10× may qualify for no-biopsy diagnosis.
EMA Result (0=Neg, 1=Pos)
Endomysial antibody (IgA). Required for no-biopsy pathway alongside tTG ≥10× ULN.
Family History (0/1)
First-degree relative with celiac disease. 10× increased risk.
Type 1 Diabetes (0/1)
Type 1 diabetes mellitus (5–10% celiac prevalence).
Other Autoimmune Disease (0/1)
Other autoimmune conditions: thyroid disease, Sjogren's, IgA deficiency, etc.

What each result means

Total Score
Combined clinical probability score (0–35).
Estimated Probability (%)
Estimated pre-test probability of celiac disease.
Risk Level (0–3)
0 = low, 1 = moderate (consider testing), 2 = high (biopsy rec), 3 = very high.
Symptom Score
Points from clinical symptoms and manifestations.
Serology Score
Points from serological test results.
No-Biopsy Pathway (0/1)
1 = eligible (tTG ≥10× ULN + EMA positive). Based on ESPGHAN criteria.
Next Step (0–3)
0 = no testing, 1 = tTG-IgA testing, 2 = biopsy recommended, 3 = no-biopsy diagnosis possible.

How this is calculated

Worked example, using the default values

  1. Identify Input Parameters
    4 parameters
    Chronic Diarrhea = 0, Bloating/Abdominal Pain = 0, Unexplained Weight Loss = 0, Iron-Deficiency Anemia = 0 = 11 input(s) provided
  2. Calculate Total Score
    0 = 0
  3. Calculate Estimated Probability
    Estimated Probability
    0 = 0%
  4. Calculate Risk Level
    0 = 0
  5. Calculate Symptom Score
    Symptom Score
    0 = 0

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