Desensitization Protocol Calculator

Rapid desensitization temporarily induces a state of tolerance by exposing mast cells and basophils to progressively larger amounts of the drug, rather than triggering them all at once with a full dose. Each of the 12 steps roughly doubles the previous dose within its solution, ending at the full target dose on the last step, which allows the procedure to be stopped or slowed if a reaction develops at a lower, more manageable dose.

No -- this calculator models the fixed standard 12-step, three-solution protocol, so the total duration is driven by the step interval alone (12 steps multiplied by the minutes between steps). Real-world protocols sometimes use more or fewer steps per solution depending on institutional practice and patient risk, but that variation is not reflected in this calculator's fixed 12-step schedule.

Directly and proportionally -- the starting dose is the target dose divided by the starting dilution factor, so doubling the target dose while keeping the dilution factor fixed doubles the starting dose too. A higher starting dilution factor (a more dilute first solution) lowers the starting dose for the same target dose, giving a more cautious first exposure.

No -- they are fixed reference figures drawn from published rapid-desensitization case series, not calculated from the target dose, dilution, or interval entered above. They give general context for how often breakthrough reactions occur during the standard 12-step protocol, but actual risk for a specific patient and drug should be assessed by the supervising allergist or immunologist, not read off this calculator.