Desensitization Protocol Calculator

Dose escalation schedule for drug or allergen desensitization.

Medical Disclaimer

This calculator is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about your health. Never disregard professional medical advice or delay seeking it because of results from this tool.

Inputs

Target dose (mg)

Starting dilution factor

Steps per dilution

Step interval (minutes)

Tab to move between fields

Results

Starting dose (mg)

0.1

Total steps12

Total duration (hours)3

Cumulative dose (mg)1,665

Mild reaction risk (%)30%

Severe reaction risk (%)5%

How to Use This Calculator

Enter Target dose (mg), Starting dilution factor, and Steps per dilution.
Set Step interval (minutes).
Review the Starting dose (mg) result.
Use Total steps and Total duration (hours) to inform your decision.

How the result changes with Starting dilution factor

Starting dilution factor	Starting dose (mg)
1,001	0.1
3,501	0.03
6,500	0.02
9,000	0.01

What each input means

Target dose (mg): Full therapeutic dose to be achieved (mg).
Starting dilution factor: Initial dilution (e.g. 1000 = start at 1/1000 of target dose).
Steps per dilution: Number of dose doublings within each dilution solution.
Step interval (minutes): Time between dose escalation steps.

What each result means

Starting dose (mg): Initial dose at the most dilute concentration.
Total steps: Number of dose escalation steps in the protocol.
Total duration (hours): Estimated total protocol duration.
Cumulative dose (mg): Total drug administered during the protocol.
Mild reaction risk (%): Estimated risk of mild hypersensitivity reaction.
Severe reaction risk (%): Estimated risk of severe/anaphylactic reaction.

How this is calculated

Worked example, using the default values

Identify Input Parameters
4 parameters
Target dose (mg) = 100, Starting dilution factor = 1000, Steps per dilution = 3, Step interval (minutes) = 15 = 4 input(s) provided
Calculate Starting dose
Starting dose
0.1 = 0.1
Calculate Total duration
Total duration
3 = 3