Aminoglycoside Dosing Calculator
Calculate extended-interval aminoglycoside (gentamicin/tobramycin) dosing based on adjusted body weight and renal function.
Medical Disclaimer
This calculator is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about your health. Never disregard professional medical advice or delay seeking it because of results from this tool.
Inputs
Results
Recommended Dose (7 mg/kg)
490 mg
Dosing Interval
24 hours
How to Use This Calculator
- Enter the patient's Actual Body Weight in kg, Height in cm, and Age in years.
- Enter the most recent Serum Creatinine in mg/dL and indicate whether the patient is Female (0 = No, 1 = Yes).
- The calculator computes Ideal Body Weight (Devine formula) and Adjusted Body Weight for obese patients, then estimates creatinine clearance (Cockcroft-Gault).
- Review the Recommended Dose at 7 mg/kg adjusted body weight and Dosing Interval (24h, 36h, or 48h based on CrCl).
- Check the Estimated Peak and Trough concentrations — confirm trough < 1 mcg/mL per Hartford nomogram and monitor drug levels after the first dose.
How the result changes with Actual Body Weight
| Actual Body Weight | Recommended Dose (7 mg/kg) | Dosing Interval |
|---|---|---|
| 48 | 336 mg | 24 hours |
| 118 | 607 mg | 24 hours |
| 202 | 843 mg | 24 hours |
| 272 | 1,039 mg | 24 hours |
What each input means
- Actual Body Weight
- Patient's actual body weight in kilograms.
- Height
- Patient's height in centimeters (used for ideal body weight calculation).
- Age
- Patient's age in years.
- Serum Creatinine
- Most recent serum creatinine level in mg/dL.
- Female Patient
- 0 = No (Male), 1 = Yes (Female). Adjusts CrCl and IBW calculations.
How this is calculated
Worked example, using the default values
- Identify Input Parameters4 parametersActual Body Weight = 70, Height = 170, Age = 40, Serum Creatinine = 1 = 5 input(s) provided
- Calculate Recommended DoseRecommended Dose490 = 490
- Calculate Dosing IntervalDosing Interval24 = 24
- Calculate Estimated PeakEstimated Peak28 = 28
- Calculate Estimated TroughEstimated Trough0.02 = 0.02
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