Immunosuppressant Dosing Calculator

Drug levels and dose adjustments for transplant patients.

Medical Disclaimer

This calculator is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about your health. Never disregard professional medical advice or delay seeking it because of results from this tool.

Inputs

Patient weight (kg)

Drug

Current trough level (ng/mL)

Current total daily dose (mg)

Tab to move between fields

Results

Recommended dose (mg/day)

187.5

Dose change (%)25

Trough in range (0/1)1

Status (1-3)2

Toxicity risk (0-100)0

How to Use This Calculator

Enter Patient weight (kg), Drug, and Tacrolimus.
Set Cyclosporine, Mycophenolate, and Sirolimus.
Adjust Everolimus, Current trough level (ng/mL) as needed.
Review the Recommended dose (mg/day) result.
Use Dose change (%) and Trough in range (0/1) to inform your decision.

How the result changes with Current trough level (ng/mL)

Current trough level (ng/mL)	Recommended dose (mg/day)
5	300
18	83.3
33	45.5
45	33.3

What each input means

Patient weight (kg): Patient body weight in kilograms.
Drug: Select immunosuppressant drug.
Current trough level (ng/mL): Most recent trough drug level (units vary by drug).
Current total daily dose (mg): Current total daily dose in mg (sum of all daily doses).

What each result means

Recommended dose (mg/day): Adjusted total daily dose to achieve target trough.
Dose change (%): Percentage change from current dose.
Trough in range (0/1): 1 = current trough is within therapeutic range.
Status (1-3): 1 = subtherapeutic, 2 = therapeutic, 3 = supratherapeutic.
Toxicity risk (0-100): Relative toxicity risk based on trough elevation above range.

How this is calculated

Worked example, using the default values

Identify Input Parameters
4 parameters
Patient weight (kg) = 70, Drug = 1, Current trough level (ng/mL) = 8, Current total daily dose (mg) = 150 = 4 input(s) provided
Calculate Recommended dose
187.5 = 187.5
Calculate Dose change
Dose change
25 = 25
Calculate Trough in range
Trough in range
1 = 1