Rapid Sequence Intubation Calculator
RSI drug dosing for induction agents, paralytics, and pretreatment with ET tube sizing.
About this calculator
Rapid sequence intubation dosing here follows standard weight-based emergency airway protocols: every drug dose scales linearly with patient weight, but which drug is chosen changes the multiplier dramatically. Etomidate at 0.3 mg/kg is the calculator's default induction agent because of its relative hemodynamic stability, while ketamine and propofol are both dosed at 1.5 mg/kg -- five times etomidate's per-kilogram dose -- with ketamine generally preferred when hemodynamic support is a priority and propofol favored when rapid, predictable offset matters more. Paralytic choice carries a smaller but still meaningful difference: succinylcholine at 1.5 mg/kg versus rocuronium at 1.2 mg/kg, the higher "RSI dose" of rocuronium specifically chosen so its onset approaches succinylcholine's when succinylcholine is contraindicated (such as hyperkalemia, recent major burns, or neuromuscular disease). Lidocaine (1.5 mg/kg) and fentanyl (2 mcg/kg) pretreatment doses, both optional and given roughly three minutes before induction, scale with weight alone and do not depend on which induction agent or paralytic is chosen.
Note that lidocaine pretreatment's evidence base has weakened in more recent literature -- some departments have moved away from routine use for indications like elevated intracranial pressure -- so treat it as an optional, protocol-dependent step rather than a universal standard. All weight-based doses here use total body weight; for markedly obese patients, some centers dose induction agents and paralytics by lean or ideal body weight instead -- follow local protocol if TBW dosing seems excessive. Endotracheal tube size follows the standard age-based pediatric formula for a cuffed tube (age in years divided by 4, plus 3.5, per Duracher's 2008 refinement of the earlier Khine formula, adopted in AHA PALS 2020) up to age 16, then a fixed adult default of 7.5 mm; tube depth at the lip is estimated as three times the tube's internal diameter for anyone past the neonatal window (age 0.25 years / 3 months and weight 4 kg), and as weight in kilograms plus 6 for neonates below that window. None of the tube-sizing outputs depend on patient weight (outside the neonatal depth rule) or on which induction or paralytic agent is selected.
Medical Disclaimer
This calculator is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about your health. Never disregard professional medical advice or delay seeking it because of results from this tool.
Inputs
Results
Induction Dose (mg)
21
Paralytic Dose (mg)
105
Figures current as of 2008. Source: Duracher C, Schmautz E, Martinon C, Faivre J, Carli P, Orliaguet G. Evaluation of cuffed tracheal tube size predicted using the Khine formula in children. Paediatr Anaesth. 2008;18(2):113-118.
How to Use This Calculator
- Enter Patient Weight (kg) and Age (years).
- Select the Induction Agent (Etomidate, Ketamine, or Propofol) based on hemodynamic status.
- Select Paralytic (Succinylcholine or Rocuronium) — use rocuronium if succinylcholine is contraindicated.
- Review Induction Dose (mg), Paralytic Dose (mg), Lidocaine Pretreatment, and Fentanyl Pretreatment doses.
- Confirm ET Tube Size (mm ID) and Tube Depth at Lip (cm) before intubation attempt.
How the result changes with Patient Weight
| Patient Weight | Induction Dose (mg) | Paralytic Dose (mg) |
|---|---|---|
| 35 | 10.5 | 52.5 |
| 53 | 15.9 | 79.5 |
| 105 | 31.5 | 157.5 |
| 175 | 52.5 | 262.5 |
What each input means
- Patient Weight
- Patient weight in kilograms (total body weight). Consider lean/ideal body weight dosing per local protocol for markedly obese patients.
- Patient Age (years)
- Age in years. Used for ET tube sizing.
- Induction Agent
- Select induction agent based on hemodynamic status and contraindications.
- Paralytic Agent
- Select paralytic agent for RSI.
What each result means
- Induction Dose (mg)
- Weight-based induction agent dose.
- Paralytic Dose (mg)
- Weight-based neuromuscular blocking agent dose.
- Lidocaine Pretreatment (mg)
- 1.5 mg/kg IV, given 3 min before induction (optional).
- Fentanyl Pretreatment (mcg)
- 2 mcg/kg IV, given 3 min before induction (optional).
- ET Tube Size (mm ID)
- Cuffed tube size. Age-based for pediatrics, standard for adults.
- Tube Depth at Lip (cm)
- Estimated insertion depth: 3 × tube size for everyone past the neonatal window (age ≥ 0.25 yr and weight ≥ 4 kg); weight (kg) + 6 for neonates.
- Agent Selected (1=Etom, 2=Ket, 3=Prop)
- Echo of selected induction agent for reference.
How this is calculated
Worked example, using the default values
- Identify Input Parameters4 parametersPatient Weight (kg) = 70, Patient Age (years) = 30, Induction Agent (1=Etomidate, 2=Ketamine, 3=Propofol) = 1, Paralytic Agent = 1 = 4 input(s) provided
- Calculate Induction Dose21 = 21
- Calculate Paralytic Dose105 = 105
- Calculate Lidocaine PretreatmentLidocaine Pretreatment = round(weight * 1.5 * 10) / 10105 = 105
- Calculate Fentanyl PretreatmentFentanyl Pretreatment = round(weight * 2 * 10) / 10140 = 140
Figures and sources
- Pediatric cuffed ET tube sizing formula (age/4 + 3.5, adopted in AHA PALS 2020) (2008) — Duracher C, Schmautz E, Martinon C, Faivre J, Carli P, Orliaguet G. Evaluation of cuffed tracheal tube size predicted using the Khine formula in children. Paediatr Anaesth. 2008;18(2):113-118.
Engine last updated . Checked against 2 independently-derived tests — how we verify calculators. Built by Paul Gunder, a software engineer, not a licensed financial, medical, or legal professional.
Frequently Asked Questions
Why is etomidate the default induction agent instead of ketamine or propofol?
Etomidate is dosed at 0.3 mg/kg in this calculator, a fifth of ketamine's or propofol's 1.5 mg/kg, and its relative hemodynamic stability -- it causes comparatively little drop in blood pressure -- makes it a common default choice for patients who are hypotensive or hemodynamically unstable, which is why it appears first here even though all three are legitimate induction choices depending on the clinical picture.
Why would rocuronium be chosen over succinylcholine for RSI?
Succinylcholine has contraindications where rocuronium doesn't -- notably hyperkalemia risk in burns, crush injury, or neuromuscular disease. This calculator doses rocuronium at 1.2 mg/kg specifically because that higher "RSI dose" (versus its lower 0.6 mg/kg standard paralysis dose) brings its onset time close enough to succinylcholine's to make it a reasonable substitute when succinylcholine is contraindicated.
Does switching the induction agent change the recommended ET tube size?
No -- ET tube size is derived only from patient age, never from which induction agent or paralytic is selected. Airway anatomy doesn't change based on which sedative is chosen for induction. Estimated tube depth is also age/tube-size driven for almost every patient (three times the tube's internal diameter), with one exception: for neonates (age under 0.25 years or weight under 4 kg), depth switches to a weight-based rule (weight in kg plus 6) instead, since the diameter-based rule can overestimate depth and risk an endobronchial (right-mainstem) tube position in that population.
How much does patient weight change the pretreatment doses?
Directly and proportionally -- lidocaine pretreatment (1.5 mg/kg) and fentanyl pretreatment (2 mcg/kg) are both simple weight-based calculations with no other input involved, so doubling patient weight exactly doubles both pretreatment doses. Neither depends on which induction agent or paralytic is chosen for the RSI itself. All doses in this calculator use total body weight; consult local protocol for lean/ideal body weight dosing in markedly obese patients.
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