Nephrotoxic Drug Adjustment Calculator

Dose adjustment for nephrotoxic drugs by GFR.

Medical Disclaimer

This calculator is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about your health. Never disregard professional medical advice or delay seeking it because of results from this tool.

Inputs

Age (years)

Actual Weight (kg)

Height (cm)

Serum Creatinine (mg/dL)

Sex

Normal Drug Dose (mg)

Tab to move between fields

Results

Creatinine Clearance (CG)

36.5 mL/min

Dose Adjustment61%

Adjusted Dose607.6 mg

Aminoglycoside Interval48 hours

Adjusted Body Weight67.6 kg

Ideal Body Weight65.9 kg

Adjustment TierNormal

How to Use This Calculator

Enter patient age (years), actual weight (kg), and height (cm).
Enter serum creatinine (mg/dL) and biological sex.
Enter the normal drug dose (mg) for a patient with full renal function.
Read creatinine clearance (Cockcroft-Gault, mL/min) and the recommended dose adjustment (%).
Use adjusted dose (mg) and aminoglycoside dosing interval (hours) for prescribing decisions.

How the result changes with Serum Creatinine (mg/dL)

Serum Creatinine (mg/dL)	Creatinine Clearance (CG)
3.09	23.6 mL/min
11	6.6 mL/min
20	3.6 mL/min
27	2.7 mL/min

What each input means

Age (years): Patient age.
Actual Weight (kg): Actual body weight in kg.
Height (cm): Height for ideal/adjusted body weight calculation.
Serum Creatinine (mg/dL): Current serum creatinine.
Sex: Biological sex.
Normal Drug Dose (mg): Standard dose for the medication in a patient with normal renal function.

What each result means

Creatinine Clearance (CG): Cockcroft-Gault creatinine clearance.
Dose Adjustment: Percentage of normal dose to administer.
Adjusted Dose: Recommended dose based on renal function.
Aminoglycoside Interval: Extended dosing interval for aminoglycosides.
Adjusted Body Weight: ABW used for dosing in obese patients.
Ideal Body Weight: IBW from Devine formula.

How this is calculated

Worked example, using the default values

Identify Input Parameters
4 parameters
Age (years) = 65, Actual Weight (kg) = 70, Height (cm) = 170, Serum Creatinine (mg/dL) = 2 = 6 input(s) provided
Calculate Creatinine Clearance
36.5 = 36.5
Calculate Dose Adjustment
Dose Adjustment
61 = 61
Calculate Adjusted Dose
Adjusted Dose = normalDose * (doseAdjustmentPct / 100)
607.6 = 607.6