Clinical Trial Eligibility Calculator

Oncology clinical trials typically screen candidates against a common core of organ-function criteria before protocol-specific requirements even come into play, and this calculator checks that common core: ECOG performance status, absolute neutrophil count, platelets, hemoglobin, estimated creatinine clearance, total bilirubin, and ALT/AST, each compared against thresholds seen across many published trial protocols. Creatinine clearance is estimated with the Cockcroft-Gault equation, published by Cockcroft and Gault in 1976 -- (140 minus age) times weight, times 0.85 for female patients, divided by 72 times serum creatinine. Mathematically, weight and serum creatinine are symmetric: CrCl is proportional to weight and inversely proportional to serum creatinine, so moving either input by the same proportion shifts the calculated clearance by roughly the same amount -- serum creatinine sitting "alone in the denominator" gives it no extra leverage over weight, since both carry the same exponent-1 relationship to the result. Serum creatinine dominates this calculator's sensitivity ranking for a different, non-mathematical reason: its declared input range (0.1-20 mg/dL, a 200-fold span) is far wider than weight's declared range (20-300 kg, a 15-fold span), so sweeping serum creatinine across its full allowed range moves the result more than sweeping weight across its full allowed range. A higher serum creatinine directly and inversely lowers the estimated clearance, while higher age lowers it and higher weight raises it.

Creatinine clearance is entirely independent of every other lab value this calculator collects -- ANC, platelets, hemoglobin, bilirubin, and ALT/AST have zero effect on the Cockcroft- Gault result, since renal filtration and bone-marrow or hepatic function are measuring different organ systems. The calculator reports both a strict eligibility bar (ECOG 0-1, creatinine clearance 60 mL/min or higher) and a relaxed bar (ECOG 0-2, clearance 30 mL/min or higher) side by side, since different trials set different thresholds and many protocols explicitly widen renal-function criteria for regimens without significant renally-cleared toxicity. This tool checks only the common-core criteria listed here -- it does not know a specific protocol's disease-specific inclusion/exclusion list, prior-therapy washout requirements, or concurrent-medication exclusions, all of which must still be verified against the actual trial protocol before determining true eligibility. It also applies Cockcroft-Gault to entered (actual) body weight across the full 20-300 kg range; standard clinical practice instead uses ideal or adjusted body weight in obese patients, since actual-weight Cockcroft-Gault can meaningfully overestimate clearance at the high end of that range.