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Calcimator

Clinical Trial Eligibility Calculator

Screen standard oncology clinical trial eligibility criteria including ECOG PS, organ function (ANC, platelets, Hb, CrCl, bilirubin, ALT), and Cockcroft-Gault creatinine clearance.

Inputs

Results

Creatinine clearance (mL/min)

86.4

Strict eligible (0/1)

1

Criteria passed (strict)7
Total criteria checked7
Relaxed eligible (0/1)1
Bilirubin (× ULN)0.67
ALT/AST (× ULN)0.63
How to Use This Calculator
  1. Enter patient age, diagnosis, and prior treatment history.
  2. Enter performance status (ECOG 0-4) and relevant lab values (counts, organ function).
  3. Read eligibility assessment based on common inclusion and exclusion criteria categories.
  4. Review flagged criteria to identify which factors may require sponsor waiver or protocol deviation.
  5. Consult the full protocol inclusion/exclusion list before final eligibility determination.

How the result changes with Serum creatinine (mg/dL)

Serum creatinine (mg/dL)Creatinine clearance (mL/min)Strict eligible (0/1)
2.0937.20
7.06110
1360
184.30

What each input means

Age (years)
Patient age in years.
Weight (kg)
Patient weight in kilograms for Cockcroft-Gault calculation.
Female (0=no, 1=yes)
Apply 0.85 correction factor for females in CrCl calculation.
ECOG PS (0–5)
ECOG Performance Status. Most trials require 0–1, some allow 0–2.
ANC (×10³/μL)
Absolute neutrophil count. Minimum usually 1.5 ×10³/μL.
Platelets (×10³/μL)
Platelet count. Minimum usually 100 ×10³/μL.
Hemoglobin (g/dL)
Hemoglobin level. Minimum usually 9.0 g/dL.
Serum creatinine (mg/dL)
Serum creatinine for Cockcroft-Gault CrCl calculation.
Total bilirubin (mg/dL)
Total bilirubin. Must be ≤1.5× ULN (ULN = 1.2 mg/dL).
ALT or AST (U/L)
Use the higher of ALT/AST. Limit is ≤3× ULN (or ≤5× with liver mets).
Liver metastases (0/1)
If yes, ALT/AST threshold is relaxed to ≤5× ULN instead of ≤3×.

What each result means

Creatinine clearance (mL/min)
Cockcroft-Gault estimated CrCl.
Criteria passed (strict)
Number of strict criteria met out of total.
Total criteria checked
Total strict eligibility criteria evaluated.
Strict eligible (0/1)
1 if all strict criteria met (ECOG 0–1, CrCl ≥60).
Relaxed eligible (0/1)
1 if all relaxed criteria met (ECOG 0–2, CrCl ≥30).
Bilirubin (× ULN)
Total bilirubin as a multiple of ULN (1.2 mg/dL). Must be ≤1.5.
ALT/AST (× ULN)
ALT or AST as a multiple of ULN (40 U/L). Must be ≤3 (or ≤5 with liver mets).

How this is calculated

Worked example, using the default values

  1. Identify Input Parameters
    4 parameters
    Age (years) = 60, Weight (kg) = 70, Female (0=no, 1=yes) = 0, ECOG PS (0–5) = 1 = 11 input(s) provided
  2. Calculate Creatinine clearance
    Creatinine clearance = ((140 - ageYears) * weightKg * genderFactor) / (72 * serumCreatinine)
    86.4 = 86.4
  3. Calculate Strict eligible
    Strict eligible
    1 = 1
  4. Calculate Criteria passed
    7 = 7
  5. Calculate Total criteria checked
    Total criteria checked = strictCriteria.length
    7 = 7

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